Blood test reveals how old your body really is 

immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

Now a simple blood test can reveal your biological age—how old your body really is. This was found in a new study from Uppsala University, the results of which are now being published in the open-access journal Scientific Report (Nature Publishing Group).

‘With this knowledge, it may be easier to motivate medical treatments or get a patient to change lifestyle and monitor the effect,’ says Ulf Gyllensten, Professor at the Department of Immunology, Genetics, and Pathologyone and of the authors of the article.

With time the body and the different organs age. Lifestyle factors such as smoking or stress affects molecular processes and thus how quickly we age.

Now researchers at Uppsala University have found that a simple blood test can reveal how your lifestyle affects the body’s age. They analysed a number of proteins in blood samples from 1000 people.

‘By analysing proteins in the blood one can estimate a person’s biological age, as well as weight, height and hip circumference. The protein profile is influenced by a number of lifestyle choices and certain factors accelerate the body’s biological aging, while others slow it down,’ says Ulf Gyllensten.

‘For example, smoking and soda increases the biological age up to 6 years, while consumption of fatty fish and coffee as well as exercise counteracts the aging process to the same extent,’ says Ulf Gyllensten.

Having knowledge of an individual’s biological age and monitoring changes in it during medical treatment or after lifestyle changes can make it easier for doctors to motivate a patient to complete the treatment, or to stick to the new lifestyle.

It is also possible to analyse the protein profile in dried bloodstains, which opens completely new opportunities to use the protein profile in forensic investigations to create a ’phantom picture‘ of basic body features of an offender, based on a biological sample from the crime scene.

Enroth, Bosdotter Enroth, Johansson & Gyllensten (2015):

Protein profiling reveals consequences of lifestyle choices on predicted biological aging