Cancer is difficult to treat, and many current therapies are unable to specifically target cancer cells. This is problematic for medical professionals and patients, because it limits the dose of the drug that can be safely administered, and often causes severe and debilitating side-effects.
But the Trinity scientists have now demonstrated that a class of naturally occurring enzymes — glycosidases — that are heavily overexpressed in tumour tissue can be used to trigger the release of therapeutic payloads solely at the local tumour sites where they are needed.
This finding may therefore result in the development of improved targeted cancer therapies with significantly reduced side-effects for patients.
Associate Professor in Chemistry at Trinity, Eoin Scanlan, led the multidisciplinary group. He said: “This is a really exciting discovery because it brings us closer to more targeted treatment of cancer. Some current therapies are limited due to the toxicity of the compounds, but our compounds are completely inactive until they are released by the enzymes that are naturally overexpressed at the tumour site. The active compound is then rapidly taken up by cancer cells.”
The research was carried out in the Trinity Biomedical Sciences Institute by researcher Elena Calatrava-Pérez in collaboration with Professors Thorfinnur Gunnlaugsson, Mathias Senge, and Clive Williams. The journal article describing the work was recently published in the journal Chemical Communications.