Tuesday, June 19, 2018
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multiple ageing-related diseases

How Does Dietary Restriction Extend Lifespan in Flies?

Lifespan in flies is extended by limiting the activity of a group of proteins called GATA transcription factors (TFs), giving clues to how a...
Alzheimer's Disease

Brain Activity Study Offers Potential Insight into Alzheimer’s Disease

Slightly elevated beta-amyloid levels in the brain are associated with increased activity in certain brain regions, according to a new study from the Center for...
Alzheimer’s disease

Lack of Sleep May Be Linked to Risk Factor for Alzheimer’s...

Losing just one night of sleep led to an immediate increase in beta-amyloid, a protein in the brain associated with Alzheimer’s disease, according to...
cancer therapy, melanoma, Dry Eye Disease, cancer, Myeloma, Multiple Myeloma, Crohn’s disease, Polycystic Ovary Syndrome, Sleep Deprivation, machine-learning, traumatic brain injury

New Study Finds Omega-3 Fatty Acid Supplements Ineffective in Treating Dry...

More than 16 million Americans suffer from dry eye, an often chronic condition that causes burning, itching, or stinging sensations in the eye, as...
light-emitting diode, Proteomics, nanostructures, nickel catalyst, Ultrafast lasers, liver capsular macrophages, obesity, cancer, lignin polymer, liver capsular macrophages, Ultrafast lasers, monocyte cells, cancer treatments, antibody drug, gene mutations, quantum-entangled photons, gut microbes, skin aging, stroke, machine learning, Cloned tumors, cancer, Rare Skin Disease, terahertz lasers, silicon-nanostructure pixels, oral cancer, heart muscle cells, cancer, cancer stem cells, gastric cancer, microelectromechanical systems, data storage, silicon nanostructures, Drug delivery, cancer, muscle nuclei, Lithography, silicon nanostructures, Quantum matter, robust lattice structures, potassium ions, Photothermal therapy, Photonic devices, Optical Components, retina, allergy, immune cells, catalyst, Nanopositioning devices, mold templates, lung cancer, cytoskeletons, hepatitis b, cardiovascular disease, memory deficits, Photonics, pre-eclampsia treatment, hair loss, nanoparticles, mobile security, Fluid dynamics, MXene, Metal-assisted chemical etching, nanomedicine, Colorectal cancer, cancer therapy, liver inflammation, cancer treatment, Semiconductor lasers, zika virus, catalysts, stem cells, fetal immune system, genetic disease, liver cancer, cancer, liver cancer, RNA editing, obesity, Microcapsules, genetic disease, Piezoelectrics, cancer, magnesium alloy, Quantum materials, therapeutic antibodies, diabetes, 2D materials, lithium-ion batteries, obesity, lupus, surfactants, Sterilization, skin on chip, Magnetic Skyrmions, cyber-security, wound infections, human genetics, immune system, eczema, solar cells, Antimicrobials, joint disorder, genetics, cancer

Mutation Linked to Rare Skin Disease

A genetic mutation that affects the production of the skin pigment melanin is associated with a previously unknown form of Cole disease — a...
Tooth Sensorsvideo

Using Tooth Sensors to Detect Disease

An interdisciplinary team of researchers from Washington University School of Medicine in St. Louis and the School of Engineering & Applied Science is redefining...
Alzheimer’s Disease

Scientists Fix Genetic Risk Factor for Alzheimer’s Disease in Human Brain...

Using human brain cells, scientists at the Gladstone Institutes discovered the cause of—and a potential solution for—the primary genetic risk factor for Alzheimer’s disease,...
video

Where You Live Could Impact your Risk for Heart Disease

Heart disease is the leading cause of death in the United States for both men and women, claiming more than 600,000 lives each year. Now, a...
Lyme Disease, influenza virus, climate change, pediatric cancer, Blood Pressure, Exoplanet, Human Pathogen, Heating and Cooling Device, Wireless Power, Electrogenetic Device, climate, Pest Damage, Battery, Game Theory, Terahertz, batteries, Water-Based Battery, fungal infections

UMD Researcher Uncovers Lyme Disease Protein Used to Outsmart the Human...

A University of Maryland (UMD) researcher has uncovered information on how the bacteria that causes Lyme disease persists in the body and fights early,...
Huntington’s diseasevideo

UW Scientists Find Excess Mitochondrial Iron, Huntington’s Disease Link

Scientists at the University of Wyoming have found that mice engineered to have Huntington’s disease (HD) have an over-accumulation of iron in their mitochondria. The...
Alzheimer’s Disease, regenerative medicine

Scientists Fix Genetic Risk Factor for Alzheimer’s Disease in Human Brain...

Using human brain cells, scientists at the Gladstone Institutes discovered the cause of—and a potential solution for—the primary genetic risk factor for Alzheimer’s disease,...
Alzheimer’s disease

Blood Test Indicates Risk of Developing Alzheimer’s Disease

There is as yet no cure for Alzheimer's disease. It is often argued that progress in drug research has been hampered by the fact...
human renal disorders

Massive Single-cell Survey of Kidney Cell Types Reveals New Paths to...

The kidney is a highly complex organ – far beyond a simple filter. Its function requires intricate interactions between many highly specialized cell types...
Alzheimer’s Disease

Blood Test Indicates Risk of Developing Alzheimer’s Disease

There is as yet no cure for Alzheimer's disease. It is often argued that progress in drug research has been hampered by the fact...
brain tumours, Common drugs, diabetes, chronic wounds, magnetism, intestinal tumours, molecular scissors, disease, genetic, immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

Common Drugs Affect Biomarkers for Heart Disease, Cancer, Inflammation

Antihypertensive treatment as well as lipid-lowering medication is often used for extensive periods of time, sometimes life-long, in many cases with few or none...
kidney function

Kidney Age, Not Kidney Disease

From the Universities of Oxford, Bristol and Johannesburg, the researchers argue that for some people a reduced level of kidney function is not necessarily a disease,...
inflammatory bowel disease

Researcher Gets $200,000 Grant to Study Inflammatory Bowel Disease

Dr. David Padua, an assistant professor of medicine in the David Geffen School of Medicine at UCLA, and a collaborator at Stanford University, have...
microfluidic chip

NUS Scientists Develop Novel Chip for Fast and Accurate Disease Detection...

A novel invention by a team of researchers from the National University of Singapore (NUS) holds promise for a faster and cheaper way to...
thyroid eye disease

Research Finds Orbital Radiotherapy Should Not Be Used to Treat Thyroid...

However, disease severity was reduced in patients who also received antiproliferative immunosuppressive drugs if they were able to tolerate these medications.  The study, led...
Bone Disease

Once-Mysterious ‘Atacama Skeleton’ Illuminates Genetics of Bone Disease

The skeleton, discovered in a leather pouch behind an abandoned church, was pristine: a tiny figure, just six inches long, with a cone-shaped head,...