Hearing Aids Improve Brain Function and Memory in Older Adults

One of the most prevalent health conditions among older adults, age-related hearing loss, can lead to cognitive decline, social isolation and depression. However, new research from the University of Maryland Department of Hearing and Speech Sciences (HESP) shows that the use of hearing aids not only restores the capacity to hear, but can improve brain function and working memory.

The UMD-led research team monitored a group of first-time hearing aid users with mild-to-moderate hearing loss over a period of six months. The researchers used a variety of behavioral and cognitive tests designed to assess participants’ hearing as well as their working memory, attention and processing speed. They also measured electrical activity produced in response to speech sounds in the auditory cortex and midbrain.

At the end of the six months, participants showed improved memory, improved neural speech processing, and greater ease of listening as a result of the hearing aid use. Findings from the study were published recently in Clinical Neurophysiology and Neuropsychologia.

“Our results suggest that the benefits of auditory rehabilitation through the use of hearing aids may extend beyond better hearing and could include improved working memory and auditory brain function,” said HESP Assistant Professor Samira Anderson, who led the research team. “In effect, hearing aids can actually help reverse several of the major problems with communication that are common as we get older.”

According to the National Institutes of Health, as many as 28.8 million Americans could benefit from wearing hearing aids, but less than a third of that population actually uses them. Several barriers prevent more widespread use of hearing aids—namely, their high cost and the fact that many people find it difficult to adjust to wearing them. A growing body of evidence has demonstrated a link between hearing loss and cognitive decline in older adults. Aging and hearing loss can also lead to changes in the brain’s ability to efficiently process speech, leading to decreased ability to understand what others are saying, especially in noisy backgrounds.

The UMD researchers say the results of their study provide hope that hearing aid use can at least partially restore deficits in cognitive function and auditory brain function in older adults.

“We hope our findings underscore the need to not only make hearing aids more accessible and affordable for older adults, but also to improve fitting procedures to ensure that people continue to wear them and benefit from them,” Anderson said.

The research team is working on developing better procedures for fitting people with hearing aids for the first time. In addition to Anderson, the team includes post-doctoral fellow Hanin Karawani and UMD alumna Kimberly Jenkins from HESP.

The study was funded by the Hearing Health Foundation and the National Institutes of Health (NIDCD R21DC015843).

Source : University of Maryland

NIH Study Uncovers Clues About Why Common Cancer Drug Causes Hearing Loss

Scientists have found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Using a highly sensitive technique to measure and map cisplatin in mouse and human inner ear tissues, researchers found that forms of cisplatin build up in the inner ear. They also found a region in the inner ear that could be targeted for efforts to prevent hearing loss from cisplatin. The study is published inNature Communications(link is external), and was supported by the National Institute on Deafness and other Communications Disorders (NIDCD), part of the National Institutes of Health.

Cisplatin and similar platinum-based drugs are prescribed for an estimated 10 to 20 percent of all cancer patients. The NIH’s National Cancer Institute supported research that led to the 1965 discovery of cisplatin and continued development leading to its success as an essential weapon in the battle against cancer. The drugs cause permanent hearing loss in 40 to 80 percent of adult patients and at least half of children who receive the drug. The new findings help explain why cisplatin is so toxic to the inner ear, and why hearing loss gets worse after each treatment, can occur long after treatment, and is more severe in children than adults.

“Hearing loss can have a major impact on a person’s life,” said James F. Battey, Jr., M.D., Ph.D., director of NIDCD. “Many adults with hearing loss struggle with social isolation and depression, among other conditions. Children who lose their hearing often have problems with social development and keeping up at school. Helping to preserve hearing in cancer patients who benefit from these drugs would be a major contribution to the quality of their lives.”

Lisa L. Cunningham, Ph.D., chief of the NIDCD Section on Sensory Cell Biology, led the research team, which included scientists from the National Institute on Minority Health and Health Disparities (NIMHD) and the National Center for Advancing Translational Sciences (NCATS). Support for data analysis was provided by Electro Scientific Industries, Inc., of Bozeman, Montana.

In most areas of the body, cisplatin is eliminated within days or weeks after treatment, but in the inner ear, the drug remains much longer. Previous research focused on why the inner ear is more sensitive than other parts of the body to cisplatin-induced damage. The NIH team pursued a new angle on the problem:  What if the inner ear is not able to get rid of cisplatin, and cells in the inner ear important for hearing die because they are exposed to the drug for a long time?

The team developed a mouse model that represents cisplatin-induced hearing loss seen in human patients. By looking at inner ear tissue of mice after the first, second, and third cisplatin treatment, researchers saw that cisplatin remained in the mouse inner ear much longer than in most other body tissues, and that it builds up with each successive treatment. They also studied inner ear tissue donated by deceased adult patients who had been treated with cisplatin, and observed that cisplatin is retained in the inner ear many months or years after treatment. In addition, when they examined inner ear tissue from one child, they found cisplatin buildup that was even higher than seen in adults. These results suggest that the inner ear readily takes up cisplatin, but it has very little ability to remove the drug.

In mice and human tissues, the research team saw the highest buildup of cisplatin in a part of the inner ear called the stria vascularis, which helps maintain the positive electrical charge in inner ear fluid that certain cells need to detect sound. The research team determined that the accumulation of cisplatin in the stria vascularis portion of the inner ear contributed to cisplatin-related hearing loss.

“Our findings suggest that if we can prevent cisplatin from entering the stria vascularis in the inner ear during treatment, we may be able to protect cancer patients from developing cisplatin-induced hearing loss,” said Cunningham.

The study was funded by the Intramural Research Program at NIDCD (ZIA DC000079-07) and NIMHD.

Source : National Institutes of Health (NIH)