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Antibody, Diabetes

Scripps Florida Scientist Awarded $2.5 Million Collaborative Grant to Develop New...

Patrick R. Griffin, co-chair of the Department of Molecular Medicine on the Florida campus of The Scripps Research Institute (TSRI), has been awarded a...
obesity

Scientists Find Way to Convert Bad Body Fat into Good Fat

There’s good fat and bad fat in our bodies. The good fat helps burn calories, while the bad fat hoards calories, contributing to weight...
Skin patch

Skin Patch Dissolves Fat, Could Help Treat Diabetes

Scientists have devised a medicated skin patch that can turn energy-storing white fat into energy-burning brown fat locally while raising the body's overall metabolism....
cancer

Scientists Discover the Engine That Powers Cancer-Killing NK Cells

Scientists have just discovered how the engine that powers cancer-killing cells functions. Crucially, their research also highlights how that engine is fuelled and that...
liver cancer

Chronic Cell Death Promotes Liver Cancer

Liver cancer (hepatocellular carcinoma) used to be among the less common cancer types in Germany. In recent decades, however, the numbers of people diagnosed...
photonics, inflammation, Dengue Treatment, HIV Drugs, glaucoma, sperm, cell biology, antioxidant, lung cancer, cancer therapy, medical imaging, explosives, integrated laser, Bosma arhinia microphthalmia syndrome, Optoelectronics, blood cells, bile duct cancer

Dissolving Obstacles to a Useful Pigment

A common plant pigment that is also a potent antioxidant could soon be a mainstream health supplement, as A*STAR researchers get closer to making...
kidney health

Reducing Endocannabinoid System’s Activity May Help Protect the Kidney Health of...

A new study provides insights on the mechanisms behind the development of kidney damage due to obesity. The findings, which appear in an upcoming...
heat generation

Plan B for Heat Generation

Brown adipose tissue is found in almost all mammals, including humans. Its cells produce heat by oxidizing sugars and fatty acids. The thermogenic protein...
genetic, immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

Genetic Effects Are Influenced by Lifestyle

In the current study, researchers have investigated if genetic effects are influenced by different lifestyle factors such as diet, smoking, socio-economic status, alcohol consumption...
gestational diabetes

Altered Metabolic Profiles Seen in Mothers Who Develop Gestational Diabetes

King’s researchers from the Faculty of Life Sciences and Medicine have found differences in the metabolic profiles of obese mothers who develop gestational diabetes...
Sleep apnea

More Evidence: Untreated Sleep Apnea Shown to Raise Metabolic and Cardiovascular...

Sleep apnea, left untreated for even a few days, can increase blood sugar and fat levels, stress hormones and blood pressure, according to a...
Sleep Apnea

Untreated Sleep Apnea Shown to Raise Metabolic and Cardiovascular Stress

Sleep apnea, left untreated for even a few days, can increase blood sugar and fat levels, stress hormones and blood pressure, according to a...
obese adults

Study Examines Dietary Fats’ Impact on Healthy, Obese Adults

Metabolically healthy obese adults consuming a diet high in unsaturated fat and low in saturated fat may be able to decrease their total cholesterol...
fat cells

Nanoparticle-Drug Combo Turns White Fat to Brown Fat with Potential to...

In a potential breakthrough for the treatment of obesity and diabetes, Purdue University scientists have found a way to deliver a drug directly to...
obesity

Brain’s Self-Regulation in Teens at Risk for Obesity

In a small study that scanned the brains of teenagers while exposing them to tempting “food cues,” researchers report that reduced activity in the...
bone loss

Study Paves the Way to a Novel Treatment for Bone Loss

Experiments with mice conducted at the University of São Paulo (USP) in Ribeirão Preto, Brazil, suggest that inhibiting the action of a protein called...
obesity

Gene Therapy via Skin Could Treat Diseases Such as Obesity

A University of Chicago-based research team has overcome challenges that have limited gene therapy and demonstrated how their novel approach with skin transplantation could...
body clock

UVA Researchers Identify Neurons That Control Brain’s Body Clock

Neurons in the brain that produce the pleasure-signaling neurotransmitter dopamine also directly control the brain’s circadian center, or “body clock” – the area that...
heart

Even Small Weight Gain Is Bad for the Heart

Modest weight gains – even among those who aren’t overweight – can cause dangerous changes to the heart, but small amounts of weight loss...
immune cells

Voracious Eater? Brain’s Immune Cells May Be at Fault

Immune cells in the brain trigger overeating and weight gain in response to diets rich in fat, according to a study in mice. The...