Monday, October 15, 2018
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Optogenetics

Mutations, Drugs Drive Cancer by Blurring Growth Signals

Genetic mutations in a form of non–small cell lung cancer (NSCLC) may drive tumor formation by blurring cells’ perception of key growth signals, according...
Dental plaque

Dental Plaque Is No Match for Catalytic Nanoparticles

Combine a diet high in sugar with poor oral hygiene habits and dental cavities, or caries, will likely result. The sugar triggers the formation...
cancer therapy, melanoma, Dry Eye Disease, cancer, Myeloma, Multiple Myeloma, Crohn’s disease, Polycystic Ovary Syndrome, Sleep Deprivation, machine-learning, traumatic brain injury

How Might Baking Soda Boost Cancer Therapy?

Cells enter a state of dormancy as tissues starved of oxygen become increasingly acidic, according to new research led by investigators from the Perelman School...
batteries and fuel cells

Paving the Way for Safer Smaller Batteries and Fuel Cells

Fuel cells and batteries provide electricity by generating and coaxing positively charged ions from a positive to a negative terminal which frees negatively charged...
Spacecraftvideo

NASA Spacecraft Discovers New Magnetic Process in Turbulent Space

Though close to home, the space immediately around Earth is full of hidden secrets and invisible processes. In a new discovery reported in the...
microparticles

A Faster Way to Make Drug Microparticles

Pharmaceuticals owe their effects mostly to their chemical composition, but the packaging of these drugs into specific physical formulations also needs to be done...
brain disorders

Putting Proteins in Their Proper Place: Penn Study Identifies System that...

A host of special molecules called nuclear RNA-binding proteins (RBPs), when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders,...
Diabetes Drug

Most Widely Prescribed Diabetes Drug Improves Nicotine Withdrawal Symptoms in Animal...

Metformin, the most widely used medication for diabetes, has also been shown to help treat dementia and some cancers. New research from the Perelman School...
Cancer Genome Atlas

Machine Learning Finds Tumor Gene Variants and Sensitivity to Drugs in...

Matching unique genetic information from cancer patients’ tumors with treatment options – an emerging area of precision medicine efforts – often fails to identify...
human renal disorders

Massive Single-cell Survey of Kidney Cell Types Reveals New Paths to...

The kidney is a highly complex organ – far beyond a simple filter. Its function requires intricate interactions between many highly specialized cell types...
human anatomy

Newly Described Feature of Human Anatomy Could Have Implications for an...

A system of interconnected, fluid-filled compartments lies below the skin’s surface, lining the digestive tract, lungs and urinary systems, and around arteries, veins, and...
Fight Age-Related Diseases

Boosting Enzyme May Help Improve Blood Flow, Fitness in Elderly

As people age, their blood-vessel density and blood flow decrease, which is why it’s harder to maintain muscle mass after 40 and endurance in...
Epigenetic Landscape

“Epigenetic Landscape” is Protective in Normal Aging, Impaired in Alzheimer’s Disease

Although certain genetic variants increase the risk of Alzheimer’s disease (AD), age is the strongest known risk factor. But the way in which molecular...
lung stem cell

New-found Stem Cell Helps Regenerate Lung Tissue after Acute Injury

Researchers have identified a lung stem cell that repairs the organ’s gas exchange compartment, according to a new study from the Perelman School of Medicine at...
gene editing

Gene-editing Reduces Triglycerides, Cholesterol by Up to 50 Percent, Finds Penn...

Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower...
sepsis

Gut Microbes Protect Against Sepsis, According to Penn Mouse Study

Sepsis occurs when the body’s response to widespread bacterial infection or toxins in the blood damages tissues and organs. The right kind of gut...
genome

“Icebreaker” Protein Opens Genome for T cell Development, Penn Researchers Find

Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions....
Brain Immune System

Brain Immune System is Key to Recovery from Motor Neuron Degeneration

The selective demise of motor neurons is the hallmark of Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis (ALS). Yet neurologists have suspected...
gene expression

Clock Protein Controls Daily Cycle of Gene Expression by Regulating Chromosome...

It’s well known that the human body functions on a 24-hour, or circadian, schedule. The up-and-down daily cycles of a long-studied clock protein called...
Electronic Transistors

Penn Engineering Research Gives Optical Switches the ‘Contrast’ of Electronic Transistors

Current computer systems represent bits of information — the 1’s and 0’s of binary code — with electricity. Circuit elements, such as transistors, operate on these electric signals,...