Saturday, April 21, 2018
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Diabetes Drug

Most Widely Prescribed Diabetes Drug Improves Nicotine Withdrawal Symptoms in Animal...

Metformin, the most widely used medication for diabetes, has also been shown to help treat dementia and some cancers. New research from the Perelman School...
Cancer Genome Atlas

Machine Learning Finds Tumor Gene Variants and Sensitivity to Drugs in...

Matching unique genetic information from cancer patients’ tumors with treatment options – an emerging area of precision medicine efforts – often fails to identify...
human renal disorders

Massive Single-cell Survey of Kidney Cell Types Reveals New Paths to...

The kidney is a highly complex organ – far beyond a simple filter. Its function requires intricate interactions between many highly specialized cell types...
human anatomy

Newly Described Feature of Human Anatomy Could Have Implications for an...

A system of interconnected, fluid-filled compartments lies below the skin’s surface, lining the digestive tract, lungs and urinary systems, and around arteries, veins, and...
Fight Age-Related Diseases

Boosting Enzyme May Help Improve Blood Flow, Fitness in Elderly

As people age, their blood-vessel density and blood flow decrease, which is why it’s harder to maintain muscle mass after 40 and endurance in...
Epigenetic Landscape

“Epigenetic Landscape” is Protective in Normal Aging, Impaired in Alzheimer’s Disease

Although certain genetic variants increase the risk of Alzheimer’s disease (AD), age is the strongest known risk factor. But the way in which molecular...
lung stem cell

New-found Stem Cell Helps Regenerate Lung Tissue after Acute Injury

Researchers have identified a lung stem cell that repairs the organ’s gas exchange compartment, according to a new study from the Perelman School of Medicine at...
gene editing

Gene-editing Reduces Triglycerides, Cholesterol by Up to 50 Percent, Finds Penn...

Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower...
sepsis

Gut Microbes Protect Against Sepsis, According to Penn Mouse Study

Sepsis occurs when the body’s response to widespread bacterial infection or toxins in the blood damages tissues and organs. The right kind of gut...
genome

“Icebreaker” Protein Opens Genome for T cell Development, Penn Researchers Find

Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions....
Brain Immune System

Brain Immune System is Key to Recovery from Motor Neuron Degeneration

The selective demise of motor neurons is the hallmark of Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis (ALS). Yet neurologists have suspected...
gene expression

Clock Protein Controls Daily Cycle of Gene Expression by Regulating Chromosome...

It’s well known that the human body functions on a 24-hour, or circadian, schedule. The up-and-down daily cycles of a long-studied clock protein called...
Electronic Transistors

Penn Engineering Research Gives Optical Switches the ‘Contrast’ of Electronic Transistors

Current computer systems represent bits of information — the 1’s and 0’s of binary code — with electricity. Circuit elements, such as transistors, operate on these electric signals,...
bone marrow

By Altering Bone Marrow, ‘Training’ Can Prepare Innate Immune System for...

When you receive a vaccine against a disease like polio or influenza, your immune system gears up to defend against that particular infection. If...
regenerative medicine

Penn Study on Super-silenced DNA Hints at New Ways to Reprogram...

Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in...
blood clots

How and Why Blood Clots Shrink

Blood clotting is the “Jekyll and Hyde” of biological processes. It’s a lifesaver when you’re bleeding, but gone awry, it causes heart attacks, strokes...
cancer, Myeloma, Multiple Myeloma, Crohn’s disease, Polycystic Ovary Syndrome, Sleep Deprivation, machine-learning, traumatic brain injury

Vitamin D May be Key for Pregnant Women with Polycystic Ovary...

Vitamin D may play a key role in helping some women seeking treatment for polycystic ovary syndrome (PCOS)-related infertility get pregnant. PCOS is a...
Heart Valves

Blood Flow in the Developing Heart Guides Maturation of Heart Valves

Congenital heart valve defects appear in 2 percent of all live births, making them the most common type of birth defect. While some of...
ovarian cancer

Scientists Track Ovarian Cancers to Site of Origin: Fallopian Tubes

Some scientists have suspected that the most common form of ovarian cancer may originate in the fallopian tubes, the thin fibrous tunnels that connect...
hand transplant, ovarian cancer, genes, zika vaccine, Pregnancy

Pregnancy-Related Heart Failure Strikes Black Women Twice as Often as Those...

African American women were found to be twice as likely to be diagnosed with peripartum cardiomyopathy as compared to women of Caucasian, Hispanic/Latina, Asian,...