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malaria

Largest Genetic Study of Mosquitoes Reveals Spread of Insecticide Resistance Across...

The largest-ever genetic study of mosquitoes reveals the movement of insecticide resistance between different regions of Africa and finds several rapidly evolving insecticide resistance...
acute myeloid leukaemia

Unforseen New Drug Target Discovered for Acute Myeloid Leukaemia (AML)

A study has found an unexpected new drug target for acute myeloid leukaemia (AML) that could open new avenues to develop effective treatments against...
Genomic surveillance

Study Shows Routine Genomic Surveillance of MRSA Can Detect Unsuspected Outbreaks

Genomic surveillance has revealed the first complete picture of MRSA spread across the east of England. Researchers from the Wellcome Trust Sanger Institute and...
Mutations

1 to 10 Mutations Are Needed to Drive Cancer, Scientists Find

For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more...
drug resistance

Yeast Spotlights Genetic Variation’s Link to Drug Resistance

Researchers have shown that genetic diversity plays a key role in enabling drug resistance to evolve. Scientists at the Wellcome Trust Sanger Institute and...
bone cancer

New Drug Hope for Patients with Rare Bone Cancer

Patients with a rare bone cancer of the skull and spine – chordoma – could be helped by existing drugs, suggest scientists from the...
stem cells

New Type of Stem Cell Line Produced Offers Expanded Potential for...

Researchers at the Wellcome Trust Sanger Institute and their collaborators have created Expanded Potential Stem Cells (EPSCs) in mice, for the first time, that...
brain function, post-traumatic stress disorder, X chromosome, Maternal Fatty Acid, chronic sciatica, preemie blindness, gliomas, breast cancer, Combination immunotherapy, prostate cancer, acute heart failure, Metastatic lymph nodes, obesity, spontaneous coronary artery dissection, movement disorder, Safe-sleep, electronic cigarettes, prostate cancer, radiation therapy, neonatal disease, chemotherapy, tumor cells, X-linked disorders, autoimmune disease, neurological disorder, transplantation, tumor cells, Pulmonary Fibrosis, Nerve-damage Disorder, Mature B Lymphocytes, Alzheimer's Disease, hepatitis c infection, depression, penicillin, Leukemia, Anti-Angiogenesis, diabetes, conversion disorder, lymphoma, kidney disease, cancer, diabetes, autism, Tourette syndrome

Gene Variant Could Lead to Missed Type 2 Diabetes Diagnosis in...

In the largest study of its kind, an international research team has identified 60 gene variants – 42 for the first time – that...
osteoporosis

Scientists Link 153 New Genetic Variants to Osteoporosis in Largest Ever...

Osteoporosis is defined by deterioration in bone structure, and commonly results in fractures. It affects 50 per cent of women and 20 per cent...
fatty liver, stroke, sleeping sickness, Sight Loss

Gene Study Sheds Light on Middle-Age Sight Loss

Their findings aid understanding of a genetic condition that causes sight loss for one in 3,000 people in the UK. They will be presented at...
fatty liver, stroke, sleeping sickness, Sight Loss

Parasite Insight May Help Curb Sleeping Sickness

When two types of sleeping sickness parasite infect the same animal at the same time, signalling between the species appears to help them compete...
bowel cancer

Bowel Cancer Study Reveals Impact of Mutations on Protein Networks

For the first time, scientists have completed a detailed study of many of the proteins in bowel cancer cells. Scientists from the Wellcome Trust...
breast cancer cells

New Genetic Analysis Reveals Late Spread of Breast Cancer and Backs...

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development,...
malaria

Largest Study of Malaria Gene Function Reveals a Finely Tuned Genome...

The malaria parasite’s success is owed to the stripping down of its genome to the bare essential genes, scientists at the Wellcome Trust Sanger...
liver disease

Artificial Bile Ducts Grown in Lab and Transplanted into Mice Could...

Our work has the potential to transform the treatment of bile duct disorders Ludovic Vallier In research published in the journal Nature Medicine, the researchers grew...
Inflammatory Bowel Disease

Inflammatory Bowel Disease: Scientists Zoom in on Genetic Culprits

Scientists have closed in on specific genes responsible for Inflammatory Bowel Disease (IBD) from a list of over 600 genes that were suspects for...
microbiome

The Bug Hunters and the Microbiome

When we think about spreading bugs, we often focus on pathogens and disease. The truth is, there’s probably an element of spreading health through...
cardiovascular disease

Isolated Greek Villages Reveal Genetic Secrets That Protect Against Heart Disease

A genetic variant that protects the heart against cardiovascular disease has been discovered by researchers at the Wellcome Trust Sanger Institute and their collaborators....
malaria

Natural Resistance to Malaria Linked to Variation in Human Red Blood...

Researchers have discovered that protection from the most severe form of malaria is linked with natural variation in human red blood cell genes. A...
genetic mutations

How Genetic Mutations Affect Development More Complex than Previously Thought

A large-scale study, published in Wellcome Open Research and which passed peer review today, has shown that inactivating the same gene in mouse embryos...