Green Tea Targets Tumors

A component of green tea can help deliver drugs to tumors in the body

spintronics, cancer cells, synchrotrons, Chemoresistance, Thermochromism, shape memory alloys, drug discovery, polymers, semiconductor, machine-learning, tapeworm infections, Polymers, carbon fiber, polymer coatings, Machine Learning, liver regenerates, breast cancer, biochemistry, Quantum Optics, Human Genome, cancer, Thermoelectric materials, optical devices, Black phosphorus, lupus, digital twins, White blood cells, embryonic stem cells, robot, cancer cells, Regenerative medicine, Gut bacteria, antibiotics, cancer and aging, hydrogen gas, catalyst, 2D Semiconductors, chronic hepatitis B, Blood cells, Iron oxide nanoparticles, lightweight structural panels, gene expression, nanoscale optical antenna, fuel cells, Monopeptides, aluminum-oxide ceramic composite, immortalizing enzyme, wearable technology, infrared systems, 2D materials, flowing water, eating disorders, semiconductor lasers, nanofluidics, machine learning, public bus networks, water splitting, obesity and inflammation, Inflammatory Bowel Disease, eczema, Machine Learning, drug resistance, immune cells, potential of phosphorene, Microfluidics, rechargeable batteries, mast cells, cell cycle, damaged lungs, packaging polymers, optical lenses, metallic foam, gastric cancer, stomach cancer, Embryo, green tea

Wrapping an anticancer drug in a nanoscale case made of a polymer and a component of green tea is an extremely effective way to deliver high doses of the drug to tumors, an A*STAR team has shown1. They demonstrated the system’s potential by using it to inhibit the growth of liver tumors in mice.

The molecules of some polymers are water attracting (hydrophilic) on one end and water repellent (hydrophobic) on the other. When placed in water, such polymers form nanoscale balls known as micelles with their hydrophilic ends facing outward. These micelles make excellent vehicles for transporting drugs to a desired site in the body.  That is because an insoluble drug can be stashed in the hydrophobic core of the micelle, preventing it from harming other tissues until it is released at the tumor, while the hydrophilic outer surface enables the micelle to travel in the bloodstream. Micelles can be designed to target tumors through various mechanisms.

Although polymeric micelles have been well studied, in clinical trials they have generally failed to live up to expectations. Their poor performance was down to their low drug-loading capacity — often they can carry only about 10 per cent of their total weight — and their instability, which causes them to break up and offload their cargo before reaching a target, damaging healthy tissue.

Now, Motoichi Kurisawa at the A*STAR Institute of Bioengineering and Nanotechnology, and colleagues, have shown that micelles with hydrophilic tips made of the polymer poly(ethylene glycol), commonly known as PEG, and hydrophobic tails of epigallocatechin gallate (EGCG) — a component of green tea — overcome both these problems. The researchers found that the micelles had a remarkably high drug-loading capacity of over 80 per cent for the anticancer drug doxorubicin. They were also stable in the bloodstream.

“We didn’t expect such a high loading capacity,” says Kurisawa. “Usually micelles become unstable as you increase their drug-loading capacity, and yet our micellar nanocomplexes are soluble in water. That came as a surprise both to us and to some of the reviewers of the paper, who asked us to check our work. But we confirmed the results.”

The results also demonstrated the versatility of the micelles. “In a previous study, we utilized the protein antibody drug (see earlier highlight); this time, we used a small drug,” says Kurisawa. “This is the advantage over existing systems: EGCG can interact with different types of drugs, including antibodies, proteins, small drugs and even nucleic acid. However, specific polymer drug carriers have to be designed to encapsulate specific drugs in conventional techniques.”

In addition to being useful for transporting anti-cancer drugs, EGCG is also known to be a powerful anti-oxidant with anti-cancer properties.  The team is now exploring this synergism.

The A*STAR-affiliated researchers contributing to this research are from the Institute of Bioengineering and Nanotechnology.

Source : A*STAR Research