A startling discovery published today in the journal Science reveals how your past history of minor bacterial infections can add up with age to cause a severe inflammatory disease.
Small bacterial infections that may go unnoticed and which the body easily clears without treatment, such as occurs during mild food poisoning, nevertheless can start a chain of events that leads to chronic inflammation and potentially life-threatening colitis. These new findings may also help identify the long–mysterious origins of inflammatory bowel disease (IBD).
Researchers worked for eight years to make this breakthrough. The project was led by Jamey Marth, Ph.D., and included lead author Won Ho Yang, Ph.D.; Michael Mahan, Ph.D.; Douglas Heithoff, Ph.D.; and Peter Aziz, M.Sc., who hold joint appointments at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC Santa Barbara’s Center for Nanomedicine (CNM), in collaboration with Victor Nizet, M.D., at UC San Diego and Markus Sperandio, M.D., at the Ludwig-Maximilian University in Munich. Together they began this long-term study with a radically different hypothesis to investigate the origin of chronic inflammatory diseases spanning colitis and IBD.
Their hypothesis reflected multiple clues. First, it has become increasingly evident that the genetic makeup of an individual plays a limited role in the onset of common inflammatory diseases, including colitis and IBD. Twins show relatively small concordance for both individuals developing IBDs, for example. Such findings implicate unknown environmental factors in disease origins.
Second, the team noted that studies from other laboratories had reported seasonal bacterial infections in humans were correlated with increased diagnoses of IBD.
“Trying to determine the origin of a disease is important as it often indicates more rational and effective preventions and treatments”, says Marth.
Working from these and other hints, the team hypothesized that recurrent low–grade bacterial infections may be a trigger in the onset of chronic inflammation.
“These findings are of potential great concern to the human population,“ adds Marth. “Food contamination at these low bacterial levels is likely to be more common than we recognize, while symptoms could be nonexistent or mild and disappear in a day or two without treatment. Repeated over time, we find that such minor infections are sufficient to trigger disease months and perhaps years later, depending upon the number and timing of infections an individual has experienced over his or her lifetime.”
The good news is that ways to boost IAP levels and inhibit neuraminidase activity exist. IAP augmentation can be as simple as adding the enzyme to drinking water. Neuraminidase inhibition can be achieved using a currently marketed antiviral neuraminidase inhibitor, a drug that is used to prevent influenza viral infections.
Mahan says, “We found that both treatment approaches were similarly effective at preventing the onset of colitis. In fact, published studies by others have recently reported IAP deficiencies and high neuraminidase levels in IBD patients.”
Adds Marth, “There is an unexpected additive effect of previous infections in the likelihood of developing colitis. This environmental factor may be responsible for triggering disease among some segments of the human population.”
Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent nonprofit medical research organization that conducts world-class, collaborative, biological research and translates its discoveries for the benefit of patients. SBP focuses its research on cancer, immunity, neurodegeneration, metabolic disorders and rare children’s diseases. The Institute invests in talent, technology and partnerships to accelerate the translation of laboratory discoveries that will have the greatest impact on patients. Recognized for its world-class NCI-designated Cancer Center and the Conrad Prebys Center for Chemical Genomics, SBP employs about 1,100 scientists and staff in San Diego (La Jolla), Calif., and Orlando (Lake Nona), Fla. For more information, visit us at SBPdiscovery.org or on Facebook at facebook.com/SBPdiscovery and on Twitter @SBPdiscovery.
Source : Sanford Burnham Prebys Medical Discovery Institute (SBP)