JuStruct Combines Research on the Function of Proteins in the Brain

Alzheimer's disease
Launched JuStruct: (from left) CEO Wolfgang Marquardt, Helmholtz President Prof. Otmar Wiestler, Prof. Carsten Sachse, Prof. Dieter Willbold, Prof. Stephan Förster and Board Member Prof. Sebastian M. Schmidt. Copyright: Forschungszentrum Jülich / Ralf-Uwe Limbach

In the development of diseases such as Alzheimer’s disease, protein molecules play an important role in the brain. In order to better investigate them at the atomic level, three excellent institutes at Forschungszentrum Jülich are now pooling their expertise: they found the “Jülich Center for Structural Biology”, or JuStruct for short. In a ceremony, the platform was officially unveiled today.

“With the creation of JuStruct, we are creating an open infrastructure that systematically bundles the diversity of our structural biology methods, providing the science community with the opportunity to gain insights into molecular and cellular structures and mechanisms in cross-institutional consortia, by other means not accessible, “said Prof. Wolfgang Marquardt, Chairman of the Research Center.

Prof. Otmar Wiestler, President of the Helmholtz Association, emphasized in his welcome address that, among other things, the scientific basis for the development of new drugs is laid with JuStruct: “JuStruct makes it possible to use the most modern examination methods and in close networking neurobiological processes in the brain The Helmholtz Association makes an important contribution to solving major societal challenges. “

The new research platform is operated by the Jülich Center for Neutron Science, the Ernst Ruska Center for Microscopy and Spectroscopy with Electrons, and the Structural Biochemistry Department at the Institute of Complex Systems. Together they provide an infrastructure for all atom-resolution structural biological methods: X-ray crystallography, liquid NMR spectroscopy, solid-state NMR spectroscopy, computational structural biology, neutron scattering and spectroscopy, and cryo-electron microscopy.

However, JuStruct should not be reserved for Jülich research alone. The plans are to operate the platform as a user center in cooperation with other scientific institutions and companies.