Monday, July 22, 2019
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Tag: Biochemistry

broccoli

Microbial Changes in the Gut May Be Behind Broccoli’s Anti-Cancer Power

Along with a host of other health benefits, broccoli has been shown in research studies to play a role in slowing certain types of...
cancer cells

‘Orphan’ RNAs Make Cancer Deadlier, But Potentially Easier to Diagnose

Scientists have long known that cancer can hijack a cell’s existing regulatory circuitry and transform healthy cells into deadly malignancies. But a new discovery...
fatty liver

Disorder in the Liver

Chronic excessive caloric intake leads to the deposition of fat droplets in the liver. This condition, known as fatty liver, can cause permanent damage...
cystic fibrosis

Scientists Solve 3-D Structure of CF Protein in Active, Inactive States

Scientists at the UNC School of Medicine in collaboration with researchers at Oregon Health & Science University have resolved the three-dimensional molecular structure of...
antibiotics

Predicting the Outcome of the Arms Race Between Man and Bacteria

Growing resistance to antibiotics is a one of the most serious global health threats we are facing. There is an urgent need to develop...
metabolic syndrome

Study Reinforces Link Between Lack of Vitamin D and Metabolic Syndrome

Researchers at São Paulo State University’s Botucatu Medical School (FMB-UNESP) in Brazil have found a strong association between vitamin D deficiency and metabolic syndrome...
Parkinson’s

Mind-Controlling Molecules from Wasp Venom Could Someday Help Parkinson’s Patients

After being stung by a parasitic wasp, the American cockroach loses control of its behavior, becoming host to the wasp’s egg. Days later, the...
olives

Virginia Tech Biochemists Dip into the Health Benefits of Olives and...

The health benefits of olives— and associated natural products such as olive oil—have long been recognized and touted by proponents of the Mediterranean diet.However,...
tularemia

Molecular Map Shows How to Disable Dangerous Bioweapon

During World War II, the Soviet Red Army was forced to move their biological warfare operations out of the path of advancing Nazi troops....
mitochondria

A Map of the Cell’s Power Station

Mitochondria are the cell's power stations; they transform the energy stored in nutrients so that cells can use it. If this function is disturbed,...
Endothelial cells

New Insights into Complex Processes

The blood-brain barrier is a crucial protection mechanism: It is a highly selective physical barrier that prevents pathogens and toxins in the circulatory system...
Neurological Disease

Researchers Define Structure of Key Enzyme Implicated in Cancer, Neurological Disease

Stony Brook-led research into the structure of a key enzyme involved with cell growth regulation could offer important clues to understanding cancer and neurodegenerative...
protein complexes

Analysis of Complex Protein Interactions

The composition of specific functional protein complexes in their cellular environment can now be analysed with unprecedented resolution. The team led by junior group...
cancer cell

Study: A New Way to Slow Cancer Cell Growth

Cancer is an extremely complex disease, but its definition is quite simple: the abnormal and uncontrollable growth of cells. Researchers from the University of...
sperm, brain tumours, Common drugs, diabetes, chronic wounds, magnetism, intestinal tumours, molecular scissors, disease, genetic, immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

New findings hope for cancer patients with kidney failure

Kidney dysfunction affects more than 50 per cent of all cancer patients, and is directly linked to poor survival. Despite the high occurrence, it...
antibiotic resistance, climate change, stressed liver cells, prostate cancer, Retroviruses, specialised ribosomes, colon cancer, Sleep Loss, brain cell, bacteriophages, drug molecules, protein CD93, antibiotic resistance, antibiotic resistance, cancer, melanoma, anti myeloma, Obsessive-compulsive disorder, paper battery, genetic, Brain tumours, sperm, epigenetic, Diabetes, rheumatoid arthritis, genes, solar power, colorectal cancer, epigenetic , dementia, brain treatments, glioblastoma, bladder cancer, Genetic, tumours metastasise, cultured cells, HIV and MDR-TB, magnetic materials, blood test results, Genetics, brain tumour, sleep, motor skills, Chameleonic, gut microbiota, genes, pollutants, penicillin, brain tumours, aneurysms

​A New Principle for Epigenetic Changes Discovered

“Cells that lack tryptase start to proliferate in an uncontrolled fashion and lose their identity. If tryptase is present, it will cleave the tails...
Mitochondria

How Complex Cells Developed

Mitochondria are the powerhouse of complex cells. In order to provide cells with energy, they need proteins, which they import from the outside. A...
Alzheimer’s

Research Points to New Path for Understanding Alzheimer’s

A team of neuroscience and biochemistry researchers at Stony Brook University have announced a novel discovery that may provide a new path to research...
Zika Vaccine

Husband-Wife Team Pioneers Zika Vaccine to Last a Lifetime

A husband-wife team of biochemists at NC State is testing a one-shot vaccine that could grant lifetime immunity against the widely feared Zika virus.Drs....
crystals

Cracking Crystals to Fight Malaria

For over a century, a simple test for malaria has been to smear a drop of blood between two slides and look for crystals...