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Inflammatory Bowel Disease

A Circuitous Route to Inflammatory Bowel Disease

A genome-wide association study (GWAS) can reveal dozens, sometimes hundreds, of genetic variations linked to a disease or trait. The subsequent challenge is to discover the...
Skin Pigmentation

Skin Pigmentation Is Far More Complex Than Thought

Many studies have suggested that the genetics of skin pigmentation are simple. A small number of known genes, it is thought, account for nearly...
blood biopsies

New Techniques Give Blood Biopsies Greater Promise

Researchers at the Broad Institute of MIT and Harvard, the Koch Institute for Integrative Cancer Research at MIT, Dana-Farber Cancer Institute, and Massachusetts General...
human cells

Researchers Engineer CRISPR to Edit Single RNA Letters in Human Cells

The Broad Institute and MIT scientists who first harnessed CRISPR for mammalian genome editing have engineered a new molecular system for efficiently editing RNA...
dnavideo

A Step Forward in DNA Base Editing

Scientists at Harvard University and the Broad Institute of MIT and Harvard have developed a new class of DNA base editor that can alter...
tuberculosis

“Monkey Wrench” Molecule Jams Tuberculosis Protein

Tuberculosis has now surpassed HIV worldwide as the leading cause of death due to infectious disease. The bacteria that causes this disease,Mycobacterium tuberculosis (Mtb),...
cancer

First Draft of a Genome-wide Cancer ‘Dependency Map’

In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and...
cancer

Making Cancer Vulnerable to Immune Attack

A novel screening method developed by a team at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center — using CRISPR-Cas9 genome editing technology to test the function...
Inflammatory Bowel Disease

Inflammatory Bowel Disease: Scientists Zoom in on Genetic Culprits

Scientists have closed in on specific genes responsible for Inflammatory Bowel Disease (IBD) from a list of over 600 genes that were suspects for...
zika virusvideo

Zika Virus Likely Circulated in Americas Long Before Its Detection

The Zika virus circulated in many regions of the Americas for several months before cases of infection were detected, according to new data from...
diagnostic platform

Scientists Unveil CRISPR-based Diagnostic Platform

A team of scientists from the Broad Institute of MIT and Harvard, the McGovern Institute for Brain Research at MIT, the Institute for Medical...
genes

Some Genes Are Less Helpful than Others

In an international collaboration published in Nature, researchers have identified people with natural gene-disrupting mutations - who have a gene that has been naturally...
CRISPR-Cas9 gene editing

Appeals Board Clears Way for UC Berkeley to Receive Patent on...

The Patent Trial and Appeal Board (PTAB) of the U.S. Patent and Trademark Office (USPTO) today ruled that the inventions claimed in the pending...
brain tumors

New Hope for Children with Brain Tumors

Precision medicine — in which diagnosis and treatments are keyed to the genetic susceptibilities of individual cancers — can play a major role in...
cancer drug resistance, Genomic Data

IBM Watson Health and Broad Institute Launch Major Research Initiative to...

IBM Watson Health (NYSE: IBM) and the Broad Institute of MIT and Harvard today announced a research initiative aimed at discovering the basis of...
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Cracking the Cancer Code with Watson Genomics

Since the time of Egyptians building pyramids, we’ve known about the impact cancer has on humankind. It is the second leading cause of death...
cancer stem cells

Single-cell Analysis Supports a Role for Cancer Stem Cells in Brain...

A study analyzing brain tumor genomics on a single-cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow-growing...
cancer

Targeting Genes by the Thousands

Tim Wang came to MIT six years ago with a simple plan: He wanted to take a genetic approach to studying cancer.A PhD candidate...
microbiome

Microbiome Genes on the Move

The word “culture” typically refers to a group’s shared heritage — such as its customs, cuisine, music, and language — that connects people in...
C2c2

New CRISPR system for targeting RNA

Scientists program C2c2, discovered in bacteria as a viral defense mechanism, to manipulate cellular RNA.