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Cancer research: dramatic improvement in the efficiency of gene therapy

The journal Nano Letters reports on innovative technology developed at the Technion: safe delivery of particles that leads to the production of the anti-cancer...
brain tumor

A new weapon in the fight against children’s brain tumors

Mice with DNA damage-repair problems can help in testing new treatments 
colon cancer

How diet influences colon cancer

Study ties high-fat diet to changes in intestinal stem cells, may help explain increased cancer risk. 
prostate cancer, nanoparticles

Low Vitamin D Predicts Aggressive Prostate Cancer

Low level of vitamin D at time of surgery is linked to potentially lethal cancer in men

New direction urged to improve cancer nanotechnology

Researchers involved in a national effort to develop cancer treatments that harness nanotechnology are recommending pivotal changes in the field because experiments with laboratory...
Lomaiviticin A

Understanding the cancer-killing properties of lomaiviticin A

A Yale lab has unlocked the process by which a natural anti-cancer agent is able to bind to DNA and directly break both strands. The...
Melanoma Metastasis

Tracking Melanoma Metastasis Leads to Key Gene Discovery 

A Wilmot Cancer Institute investigator discovered a gene that’s required for the initiation of melanoma and the growth of disseminated melanoma cancer cells in...
cancer prevention

Fruits, vegetables, ‘farm-to-fork continuum’ vital to cancer prevention

After decades of research aimed at improving the yield, appearance and safety of fruits, vegetables and grains, it's time to focus science on the...
arthritis treatment, artificial metabolism, microfluidic device, pregnancy, immune cells, emotions, solitons, enzyme, schistosomiasis, infrared light, brain cancer, chronic pain, Artificial intelligence, immune response, prostate cancer, pollution mitigation, colony collapse, brain diseases, E. coli, enzyme sirtuin 6

Study reveals insights into an aggressive prostate cancer

Therapies that cut off the hormone androgen, which fuels tumor growth, are commonly used to treat patients with advanced prostate cancer. While this is...

New clues to common and elusive KRAS cancer gene

Researchers find strong interaction that could prove to be target for cancer therapies 

New handheld, pen-sized microscope could ID cancer cells in doctor’s offices...

Surgeons removing a malignant brain tumor don’t want to leave cancerous material behind. But they’re also trying to protect healthy brain matter and minimize...
sperm, brain tumours, Common drugs, diabetes, chronic wounds, magnetism, intestinal tumours, molecular scissors, disease, genetic, immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

Method for better treatment of breast cancer 

A new study shows that a novel imaging-based method for defining appropriateness of breast cancer treatment is as accurate as the current standard-of-care and...

Immunotherapy breakthrough approved as standard of care for advanced melanoma 

Pembrolizumab works by blocking the immune system's brakes, thereby allowing its T cells to attack cancer cells When compared to ipilimumab, the drug has less...