“People usually think of brain cells as communicating signals through the synapses between them,” said Emily Noble, a postdoctoral biological sciences researcher at the USC Dornsife College of Letters, Arts and Sciences. “We are showing that the brain has another complementary way to communicate by sending these signals into the cerebrospinal fluid.”
Scientists have long known that signals are sent from cell to cell or through release into blood vessels. The study, published today in the journal Cell Metabolism, shows that the brain regulates some processes by releasing and dispersing molecules, and in this case, a neuropeptide, through cerebrospinal fluid.
Hunger hormone: one fluid, many purposes
Cerebrospinal fluid has three chief assignments. First, its grueling eternal task is buoyancy, like the Greek Titan Atlas supporting the brain. Second, it acts as a cushion after a blow to the head. Third, it is the brain’s sewer system, clearing away metabolic waste.
As neuroscience technologies have advanced, scientists have seen indications that what is sometimes dismissed as sewage actually has a role in the brain’s regulation of behaviors such as stress, energy balance and reproduction.
“The cerebrospinal fluid had been historically thought more of as a metabolic wasteland,” said Scott Kanoski, the study’s corresponding author and a USC Dornsife assistant professor of biological sciences. “But what we are showing is that the fluid is an active mechanism for communication in the brain.”
For their study, the researchers focused on the molecule melanin-concentrating hormone (MCH). This neuropeptide is generated by neurons in the brain’s hunger center, the lateral hypothalamus, at the base of the brain just above the pituitary gland. MCH stimulates appetite. It also can reduce energy burn.
“When we released MCH into the cerebrospinal fluid, the animals would start eating,” Kanoski said. “When we reduced the levels of the molecule, then we saw the opposite effect and the animals would eat less.”
Based on their findings, the researchers determined the peptide’s release is likely influenced by a circadian clock and a daily mealtime routine.
The researchers have some lingering questions about the hunger molecule that they hope will be answered with further investigation: Is MCH released from the brain in some special form that protects it from damage or other degradation? How exactly does it travel into the cerebrospinal fluid and where does it go from there?
Kanoski added that they wonder what other behaviors, besides feeding, the cerebrospinal fluid helps to regulate.
Source : University of Southern California