Thursday, July 20, 2017
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cognitive development

Toddler Brain Development: Bacterial Clues Found in Dirty Baby Diapers

If you’re the parent of an infant, diaper duty probably isn’t your favorite part of the day. But you dutifully check the contents of...
blood disorders

Genome Therapy with Beneficial Natural Mutation Could Lead to New Treatment...

By introducing a beneficial natural mutation into blood cells using the gene-editing technique CRISPR, a UNSW Sydney-led team of scientists has been able to...
astrocytes

Not All Astrocytes in the Brain Are the Same, Study Finds

From afar, the billions of stars in our galaxy look indistinguishable, just as the billions of star-shaped astrocytes in our brains appear the same...
immune system

Insight into the Immune System

Fundamental new insights into the functioning of the immune system and a new approach to treating autoimmune diseases: these are among the achievements of...
drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

New Method Shortcut in Drug Development

“Finding out how a therapeutic drug affects the body means having to consider many different factors that can influence the cells’ internal environment. Our...
bipolar disorder

AI Made for Military May Aid Bipolar Treatment

New research discovers that a machine learning application designed for the military can also be used to predict treatment outcomes for bipolar disorder. Researchers at...
schizophrenia, Multiple sclerosis, collaboration, RNA modification, multiple sclerosis, spin Seebeck effect, multiple sclerosis, leukemia, Endocrine cells, short-sightedness

Erratic Time Perception in Schizophrenia

Persons suffering from schizophrenia have a different perception of time than healthy individuals. There is far more variation in the way that a time...
mental health

Mental Health Counts

Scientists of the Technical University of Munich (TUM) and Helmholtz Zentrum München asked about 3,600 participants about well-being in later life. The results, which...
lupus, dementia, digestive system, Head Impact, blood pressure, Pancreatic Cancer, Regenerative Medicine Therapies, Cardiometabolic Health, Kidney Function, Cocaine addiction, Opioid Analgesic, Asthma, Antidepressants, breast cancer

Researchers Make Significant Progress in Engineering Digestive System Tissues

Researchers at Wake Forest Institute for Regenerative Medicine have reached important milestones in their quest to engineer replacement tissue in the lab to treat...
Neurological Disorders

Brain’s Network May Provide Insights into Neurological Disorders

A deeper understanding of the brain’s connectivity network of neurons and its relationship to the organ’s deep tissue could allow researchers to predict brain...
liver disease

Artificial Bile Ducts Grown in Lab and Transplanted into Mice Could...

Our work has the potential to transform the treatment of bile duct disorders Ludovic Vallier In research published in the journal Nature Medicine, the researchers grew...
Pre-eclampsia

Aspirin Reduces Risk of Pre-eclampsia in Pregnant Women

A trial, led by Professor Kypros Nicolaides, Professor of Foetal Medicine at King’s College London, Dr Liona Poon of King’s College, London withProfessor David...
autism

Mice Provide Insight Into Genetics of Autism Spectrum Disorders

While the definitive causes remain unclear, several genetic and environmental factors increase the likelihood of autism spectrum disorder, or ASD, a group of conditions...
brain cells

Shining Light on Brain Cells That Coordinate Movement

UW Medicine researchers have developed a technique for inserting a gene into specific cell types in the adult brain in an animal model. Recent work...
pediatric feeding disorders

New Study Advances Understanding on Treatment of Pediatric Feeding Disorders

A new study suggests the existing drug D-cycloserine may enhance recovery for children during treatment for pediatric feeding disorders, by changing their brain's reaction...
cancer, diabetes, autism, Tourette syndrome

Rare Genetic Variants Found to Increase Risk for Tourette Syndrome

An international research team led by investigators at Massachusetts General Hospital (MGH) and the University of California at Los Angeles (UCLA) – along with...
brain scan

New Technique Makes Brain Scans Better

People who suffer a stroke often undergo a brain scan at the hospital, allowing doctors to determine the location and extent of the damage....
viral infections

Sedative Combats Virus That Can Cause Birth Defects

A common sedative may help combat common viral infections that can cause birth defects in developing babies, Yale researchers report June 19 in the...
chromosomes

How Cells Combat Chromosome Imbalance

Most living cells have a defined number of chromosomes: Human cells, for example, have 23 pairs. As cells divide, they can make errors that...
gene therapy

Newly Designed Viral Vectors Could Lead to Improved Gene Therapies

For many patients, participating in gene therapy clinical trials isn’t an option because their immune system recognizes and fights the helpful virus used for...