Sunday, December 16, 2018
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genotype and environmental factors

Algorithm Identifies Multiple Gene–Environment Relationships

The scientists produced an algorithm and a bioinformatics method that can be applied to large cohorts of human genome and lifestyle data to identify...
Intermittent fasting

Intermittent Fasting: No Advantage over Conventional Weight Loss Diets

Intermittent fasting helps lose weight and promotes health. However, it is not superior to conventional calorie restriction diets, scientists from the German Cancer Research...
DNA damage repair

Defective DNA Damage Repair Leads to Chaos in the Genome

Only a few years ago, scientists at the German Cancer Research Center (DKFZ), among others, described a new damage pattern in the genetic material...
breast cancer

Breast Cancer: Stress Signaling Promotes Metastasis and Therapy Resistance

Scientists from the German Cancer Research Centre (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) have identified a...
childhood brain cancer

A Faster Lane Towards Effective Therapies of Childhood Brain Cancer

Microscopic examinations of tumor tissue (histology) make it possible to differentiate several subtypes of brain cancer. However, analyses of tumor genomes and investigations at...
Cancer Therapy

Physical Exercise in Cancer Therapy – the More Individualized, the Better

Thanks to modern therapy methods, mortality from tumor diseases is decreasing. While before 1980 two thirds of cancer patients succumbed to their disease, today...
wiring diagrams

Understanding the “Wiring Diagrams” of Genes in Complex Tissues

How is the activity of all genes in cells of higher organisms interconnected? And how are the genetic "wiring diagrams" of the cells in...
brain tumors

Taking a Look at the Genes of Brain Tumors May Help...

The “Hopp Children’s Cancer Center Heidelberg” (KiTZ) is a joint initiative of the German Cancer Research Center (DKFZ), Heidelberg University Hospital and Heidelberg University. Brain...
Drug Research

Machine Learning to Accellerate Drug Research

The development of new drugs is a lengthy and expensive process. It is often only after a long development period that it becomes apparent...
Sugar Metabolism

Sugar Metabolism Controls Intestinal Regeneration

No other tissue in our body has such a high rate of cell renewal as the intestine. Since the intestinal tissue has an enormous...
medulloblastoma

New Approach Uncovers Tumor Promoting Signaling Pathway in Common Children’s Brain...

The "Hopp Children's Cancer Center at the NCT Heidelberg" (KiTZ) is a joint initiative of Heidelberg University Hospital and the German Cancer Research Center...
cancer drug

Cancer Drug – in a Different Way Than Expected

Polo-like kinase 1 (PLK1) is overexpressed in a large number of cancers, especially in fast-growing, chromosome-unstable tumors. The enzyme is involved in cell division:...
brain cancer

Brain Cancer: Typical Mutation in Cancer Cells Stifles Immune Response

The exchange of a single amino acid building block in a metabolic enzyme can lead to cancer. In addition, it can impair the immune...
Sleeping Sickness

Sleeping Sickness: Pathogens Camouflage Themselves with Sugar

It has long been known that the pathogens causing sleeping sickness evade the immune system by exchanging their surface proteins. But now scientists at...
Diabetes

Mechanism of Action of a Diabetes Drug Differs Between Males and...

The number of people with diabetes mellitus is increasing in Germany. It is now estimated that 7 to 8 percent of adults in this...
blood cancer cells

New Technique Makes Blood Cancer Cells Visible for the Immune System

Chronic lymphocytic leukemia (CLL) is the most common type of blood cancer in adults. It can be treated with chemotherapy and oral drugs but...
breast cancer

14 New Breast Cancer Risk Genes Discovered

Many genetic markers associated with the familial breast cancer risk are outside the protein-coding regions of the genome and are likely to regulate the...
aging

Key Molecule of Aging Discovered

Oxidative stress causes cells and entire organisms to age. If reactive oxygen species accumulate, this causes damage to the DNA as well as changes...
malaria

Malaria: Cooperating Antibodies Enhance Immune Response

Each year, an estimated 200 million people contract malaria and approximately 440,000 people succumb to the infectious disease. Although regarded as a tropical disease,...
breast cancer

Breast Cancer: Microproteins Essential for Cancer Growth

In women, breast cancer is the most common cancer. One in eight women suffers from a malignant tumor in her breast during her life....