Uppsala to join new European university network 

genetic, immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

Eight representatives of some of Europe’s most prominent universities gathered today in Brussels to form a network – the Guild of European Research Intensive Universities. The network is set to become an important force in the effort to strengthen research and education throughout Europe.

The Guild of European Research Intensive Universities is a network that counts Uppsala University among its initiators. Over the course of approximately one year, the University has participated in discussions on structures for collaboration with a dozen other prominent European universities.

The initiative stems from a need for the academic community to jointly address many of the societal challenges facing Europe and the world. Universities can play an important role in tackling the political, social, and scientific issues that we face today. If the European community, us included, is sincere in its desire to solve these questions, we must work together efficiently. The network will be a key factor in this mutual undertaking.

‘It is an important initiative which will see Uppsala University working together with other prominent European universities towards a common goal, particularly where EU policy is concerned. We need a stronger presence in Brussels, which this network is poised to give us’, says Vice-Chancellor Eva Åkesson.

Amongst the institutions that met in Brussels were the universities of Bologna, Glasgow, Göttingen, Groningen, Krakow (Jagiellonian) Oslo, Tübingen, Uppsala, and Warwick. Other members will be announced when the Guild is formally launched on 21 November 2016, an event that will also be held in Brussels.