Tuesday, October 15, 2019
Nephrotic syndrome

Discovery of Novel Gene Mutations Associated with Nephrotic Syndrome in Children

Nephrotic syndrome, a cluster of symptoms of kidney disease mainly evidenced by excessive urinary excretion of protein, has several causes, including genetic mutations that...
gluten intolerance

Is Your Meal Really Gluten Free?

For people with celiac disease or gluten intolerances, dining out can be stressful. Even trace amounts of the protein — found in wheat, barley,...
fragile X mental retardation protein

Neuroscience Study Identifies New Trigger Mechanism for Fragile X Syndrome in Mice

A study published today in the Journal of Neuroscience led by Yongjie Yang of Tufts University School of Medicine identifies an astroglial trigger mechanism...
Huntington Disease

Drug Helps Reduce Involuntary Movements for People with Huntington Disease

People with Huntington disease (HD) experienced fewer involuntary movements, also known as chorea,  while taking deutetrabenazine (SD-809) compared to placebo, according to a paper...
unsaturated fats

Unsaturated Fats Linked to Longer, Healthier Life

Consuming greater amounts of unsaturated fats is associated with lower mortality, according to a study from Harvard T.H. Chan School of Public Health. In...
microfluidic device

New Microfluidic Device Offers Means for Studying Electric Field Cancer Therapy

Researchers at MIT’s research center in Singapore have developed a new microfluidic device that tests the effects of electric fields on cancer cells. They...
calculator for psychosis

Risk Calculator for Psychosis Gives Clinicians a Valuable New Tool

A national consortium of researchers has developed an individual risk calculator for schizophrenia and other psychosis, comparable to those for cardiovascular disease and other...
portable Zika test

Penn Engineers Develop $2 Portable Zika Test

University of Pennsylvania engineers have developed a rapid, low-cost genetic test for the Zika virus. The $2 testing device, about the size of a...
colorectal cancer

Genetic Mutations Found Linked to Rare Cases of Multiple Bowel Tumors

Researchers have identified genetic mutations affecting the immune system which may lead to the development of more than one bowel tumour at the same...
food poisoning

UT Southwestern Study Finds Sensing Mechanism in Food Poisoning Bug

UT Southwestern Medical Center researchers have uncovered a mechanism that a type of pathogenic bacteria found in shellfish use to sense when they are...
esophageal cancer

New Detection Method Paves the Way for 100 Percent Detection of Esophageal Cancer

Recognizing the early stages of esophageal cancer is difficult because it can easily be missed. TU Eindhoven has therefore been working with the Catharina...
unconjugated bilirubin

A Fluorescent Protein from Japanese Eel Muscles Used to Detect Bilirubin in Newborns

A research group led by Project Professor Morioka Ichiro (Kobe University Graduate School of Medicine, Department of Pediatrics) and Assistant Professor Iwatani Sota (Kobe...
Irradiation

New Approach to Evaluate Irradiation Effect on Whole Body

A University of Tokyo joint research group has developed a method of applying a heavy particle beam (a beam of accelerated carbon ions) used...
robotic rectum

Robotic Rectum May Aid Prostate Cancer Diagnosis

The technology, which consists of prosthetic buttocks and rectum with in-built robotic technology, has been developed by scientists atImperial College London. The idea is the...
Programmable RNA Vaccines

Engineers Design Programmable RNA Vaccines

MIT engineers have developed a new type of easily customizable vaccine that can be manufactured in one week, allowing it to be rapidly deployed...
personalized cancer treatment

New Insights for Personalized Cancer Treatment

While each patient history is unique, there are also commonalities among cases. Of particular interest to doctors is how different patients react to a...
childhood milestones

When Did Your Child First Walk? The Answer May Be an Indicator of Future...

A child who stands earlier with assistance is a predictor of better developmental skills, independent of gestational age or birth weight, according to a...
sperm, brain tumours, Common drugs, diabetes, chronic wounds, magnetism, intestinal tumours, molecular scissors, disease, genetic, immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

Antidepressants Boost CBT for Social Anxiety

Many people feel anxious if they have to speak in front of an audience or socialise with others. If the anxiety becomes frequent and...
RNA molecules

Seeing RNA at the Nanoscale

Cells contain thousands of messenger RNA molecules, which carry copies of DNA’s genetic instructions to the rest of the cell. MIT engineers have now...
seaweed

Seaweed Instead of Salt

Without salt, many foods seem tasteless and bland. “Salt acts as a natural flavor enhancer, has a conserving effect and is essential for the...