The researchers report the discovery of special enzymes in acne bacteria that together form an enzyme system with the ability to break down N-glycans, which are carbohydrate chains that are linked to human proteins. Like other oligosaccharides, which are polymer compounds containing simple sugars, N-glycans play an important role in the body, for instance in the immune system. As part of the body’s immune response, N-glycans modify certain proteins in the body, such as antibodies, to ensure the correct structure and function in fighting antigens such as viruses and bacteria.
However, Divne says their findings suggest that the C. acnes metabolism not only enables the bacteria to make a nutritious meal of N-glycans but could also produce a mechanism that allows it to circumvent the human immune system.
“The reason that the bacterium breaks down N-glycans can be for nutrition or for overriding our defense against the bacterium,” Divne says. The researchers examined the three-dimensional atomic structure of the enzymes to get experiment support for its hypothesis, which they will continue working with.
Co-author Henrik Aspeborg says there is still more to examine. “So far, there is still very little known about how bacteria break down and metabolize human glycans,” he says.
“In a few years, when we hopefully have a more complete picture of how the acne bacteria metabolizes our N-glycans, we will be in a great position to fight back against serious forms of acne.”
Source : KTH Royal Institute of Technology