Saturday, August 17, 2019
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DNA

More ancient viruses lurk in our DNA than we thought

One whole endogenous retrovirus genome -- and bits of 17 others -- were spotted in a study of 2,500 human genomes
mosquitoes 

Lighting up disease-carrying mosquitoes 

Sandia’s QUASR enables speedy, accurate detection of West Nile and other viruses
ultra-sensitive test

Stanford chemists develop an ultra-sensitive test for cancers, HIV

Catching a disease in its earliest stages can lead to more effective therapies. Stanford chemists have increased the likelihood of detecting these diseases via...
sperm, brain tumours, Common drugs, diabetes, chronic wounds, magnetism, intestinal tumours, molecular scissors, disease, genetic, immune cells, drug development, Diabetes, Antibiotic, hydrogen generation, chronic obstructive pulmonary disease, malaria, photosynthesis, kidney failure, Brain tumours, mental health, blood cancer, cancer, dementia, cancer treatment, antibiotic resistance, blood vessel leakage, quantum simulations, atrial fibrillation, batteries, goiter treatment, terahertz radiation, organic materials , Guild of European Research Intensive Universities, gene copies, social anxiety, blue light screens, ‘Our hope is that these findings will make it possible to discover a way to selectively inhibit the TGF-beta signals that stimulate tumour development without knocking out the signals that inhibit tumour development, and that this can eventually be used in the fight against cancer,’ says Eleftheria Vasilaki, postdoctoral researcher at Ludwig Institute for Cancer Research at Uppsala University and lead author of the study. TGF-beta regulates cell growth and specialisation, in particular during foetal development. In the context of tumour development, TGF-beta has a complicated role. Initially, it inhibits tumour formation because it inhibits cell division and stimulates cell death. At a late stage of tumour development, however, TGF-beta stimulates proliferation and metastasis of tumour cells and thereby accelerates tumour formation. TGF-beta’s signalling mechanisms and role in tumour development have been studied at the Ludwig Institute for Cancer Research at Uppsala University for the past 30 years. Recent discoveries at the Institute, now published in the current study in Science Signaling, explain part of the mechanism by which TGF-beta switches from suppressing to enhancing tumour development. Uppsala researchers, in collaboration with a Japanese research team, discovered that TGF-beta along with the oncoprotein Ras, which is often activated in tumours, affects members of the p53 family. The p53 protein plays a key role in regulating tumour development and is often altered – mutated – in tumours. TGF-beta and Ras suppress the effect of mutated p53, thereby enhancing the effect of another member of the p53 family, namely delta-Np63, which in turn stimulates tumour development and metastasis.

New cancer treatment to be tested 

The Swedish Medical Products Agency and the Regional Ethics Committee have approved the initiation of a clinical trial for a completely new form of...
chronic infections

“Master switch” for chronic infections

Researchers discover immune factor that allows viral infections to become chronic
cancer

Southampton experts trial new drug to help immune system fight cancer

Cancer experts at the University of Southampton and Southampton General Hospital are trialling a new drug in head and neck cancer patients that could...
DNA

Ancient Viral Invaders in Our DNA Help Fight Today’s Infections

About eight percent of our DNA is viral in origin: remnants of ancient battles between infectious viruses and our ancestors. These so-called endogenous viruses...
potent antibodies, HIV Antibodies, pain, sarcoma, Pompe Disease

Researchers Unravel Pathways of Potent Antibodies that Fight HIV Infection

One of the most crucial and elusive goals of an effective HIV vaccine is to stimulate antibodies that can attack the virus even as...
video

IBM Scientists Invent a Thermometer for the Nanoscale

The IBM lab responsible for inventing the scanning tunneling microscope and the atomic force microscope has invented another critical tool for helping us understand the nanoworld.
zika virus

Dengue vaccine could be adapted to combat zika virus

The technology developed to formulate Brazil’s dengue vaccine, supported by FAPESP and now in the final phase of clinical trials, can be adapted to create a...
viruses

Scientists discover way to potentially track and stop human and agricultural...

Viruses are molecular thieves that take from their hosts under the cloak of darkness. But now a Virginia Tech scientist has found a way...
sensitive diagnostics

A portable device for rapid and highly sensitive diagnostics

When remote regions with limited health facilities experience an epidemic, they need portable diagnostic equipment that functions outside the hospital. As demand for such...
zika

Gene drive strategy suggested to combat harmful virus spread

With the outbreak of viruses like Zika, chikungunya, and dengue on the rise, public health officials are desperate to stop transmission.Virginia Tech experts explore...
deformed wing virus

Bee epidemic linked to colony trafficking

Just as world travel is contributing to the Zika virus epidemic spreading through Latin America and into North America, so too is world traffic...
zika

Mosquito genetics may help address Zika crisis

Professor Jeffrey Powell began working on the mosquito that transmits the Zika virus when he was an undergraduate student 49 years ago. He has...
t cells

New approach to adult T-cell leukemia therapy

A University of Tokyo research group has discovered that genome-wide epigenetic disorder is behind patterns of abnormal gene expression found in adult T-cell leukemia-lymphoma...
genes

Delivering Genes Across the Blood-Brain Barrier

Caltech biologists have modified a harmless virus in such a way that it can successfully enter the adult mouse brain through the bloodstream and...
pathogen

Improved clinical pathogen testing using innovative methods will benefit patients

JRC scientists, in collaboration with partners of a European research project, addressed measurement issues that impact on the monitoring of harmful microorganisms. They conclude...
chronic pain, HIV, cancer

HIV is still growing, even when undetectable in the blood

Study challenges previous beliefs about dormant virus and charts a “path to a cure”
herpes

Study shows how herpes virus escapes from cell nucleus

The mechanism used by the oral herpes simplex virus (HSV-1) to escape from the nucleus of its host cell after replicating has been described...