Viruses don’t always kill their microbial hosts. In many cases, they develop a mutually beneficial relationship: the virus establishes itself inside the microbe and, in return, grants its host with immunity against attack by similar viruses.
Understanding this relationship is beneficial not only for medical research and practical applications but also in marine biology, says Alison Buchan, Carolyn W. Fite Professor of Microbiology at the University of Tennessee, Knoxville.
“Marine microbes are uniquely responsible for carrying out processes that are essential for all of earth’s biogeochemical cycles, including many that play a role in climate change,” she said.
Buchan explained some of these interactions on Sunday, February 17, during the annual meeting of the American Association for the Advancement of Science in Washington, D.C.
Her talk, “It’s Only Mostly Dead: Deciphering Mechanisms Underlying Virus-Microbe Interactions,” was part of the scientific session titled Viruses, Microbes and Their Entangled Fates.
The function of a microbial community is in large part dictated by its composition: what microbes are present and how many of each.
Within the community, bacteria compete with one another for resources. In the course of this fight, some bacteria produce antibiotics and use them against other types of bacteria. This kind of interaction has been known for some time.
But there is another fight strategy that scientists like Buchan are just now considering: bacteria might use the viruses that infect them as weapons against other types of microbes.
“We have recently discovered that while they are in the process of dying, microbes can produce new viruses that then go to attack their original invader. This is a form of resistance we had not observed before,” said Buchan.
This type of competitive interaction, Buchan said, is important for stabilizing the size of microbial populations in marine systems. This balance may be crucial for biogeochemical processes, including many related to climate change.
During Sunday’s presentation, Buchan shared stage with Joshua Weitz, professor or theoretical ecology and quantitative biology at the Georgia Institute of Technology, and Matthew Sullivan, associate professor of microbiology and civil, environmental, and geodetic engineeringat the Ohio State University.